AI for Science

BABE: Biology Arena BEnchmark

JJunting ZhouJJin ChenLLinfeng HaoDDenghui CaoZZheyu WangQQiguang ChenCChaoyou FuJJiaze ChenYYuchen WuGGe ZhangMMingxuan WangWWenhao HuangTTong Yang
Published
February 5, 2026
Authors
13
Word Count
7,953

BABE: Advancing AI for complex biological reasoning.

Abstract

The rapid evolution of large language models (LLMs) has expanded their capabilities from basic dialogue to advanced scientific reasoning. However, existing benchmarks in biology often fail to assess a critical skill required of researchers: the ability to integrate experimental results with contextual knowledge to derive meaningful conclusions. To address this gap, we introduce BABE(Biology Arena BEnchmark), a comprehensive benchmark designed to evaluate the experimental reasoning capabilities of biological AI systems. BABE is uniquely constructed from peer-reviewed research papers and real-world biological studies, ensuring that tasks reflect the complexity and interdisciplinary nature of actual scientific inquiry. BABE challenges models to perform causal reasoning and cross-scale inference. Our benchmark provides a robust framework for assessing how well AI systems can reason like practicing scientists, offering a more authentic measure of their potential to contribute to biological research.

Key Takeaways

  • 1

    BABE evaluates AI's ability to reason like scientists.

  • 2

    Current models struggle with complex biological reasoning tasks.

  • 3

    BABE aims to accelerate scientific discovery with AI.

Limitations

  • Current benchmarks fail to assess interdisciplinary reasoning.

  • Existing models lack practical utility in biological research.

Keywords

large language modelsbiological AI systemsexperimental reasoningcausal reasoningcross-scale inferencepeer-reviewed research papersreal-world biological studies

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BABE: Biology Arena BEnchmark | Paperchime